This study aimed to explore the relationship between student teachers’ sense of efficacy and their teaching concerns. The participants were three hundred and thirty-nine prospective teachers enrolled in the secondary science and mathematics education departments of two universities in Turkey. Two instruments were used to collect data: ‘Teachers’ Concerns Checklist’ and Teachers’ Sense of Efficacy’. The results of this study reveal that pre-service teachers in this study had moderate senses of efficacy in terms of their efficacy in student engagement, instructional strategies and classroom management.